The Organized Crime Control Bureau (O.C.C.B.) is charged with the investigation and prevention of organized crime within New York City. This is mainly done through standard police investigation and the use of confidential informants. The Organized Crime Control Bureau has numerous units and sub-units that investigate matters such as organized auto larceny rings, unlawful firearms, and prostitution.

The Organized Crime Control Bureau utilizes undercover police officers to infiltrate various criminal organizations. The Organized Crime Control Bureau has been effective against the Five Families of the Sicilian Mafia, "the westies" of the Irish mob, and Russian organized criminal elements. The Organized Crime Control Bureau's Joint Organized Crime Task Force works in cooperation with the Federal Bureau of Investigation's New York Field Division (the largest FBI office in the US).